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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
The effect of stress in early ontogeny on behavioural characteristics of rodents
 Chumová, Petra ; Landová, Eva (advisor) ; Petrásek, Tomáš (referee)
Postnatal stress and sensory stimulation are major factors causing the acute changes in development of neuroendocrine system that can influence the expression of behavioural phenotype in adult rodents. Variability of early life environment and stress affect the development of individual through the changes of maternal care. The amount and quality of maternal care influence the function of HPA axis and stress hormone levels in pups during the hyporesponsive period, which provides them lesser vulnerability against the potential impact of stressors. This mechanism is crucial for physiological development of hippocampus, amygdale and prefrontal cortex, the brain regions that are highly important for regulation of adult behaviour. The absence of maternal care and social contact in postnatal and early weaning ontogeny are possibly the biggest stressors in rodents. While neonatal handling (brief maternal separation) has mainly positive effects on the development of emotional and cognitive abilities, prolonged and repeated maternal separation and early weaning result in stress-response alterations and long-lasting impairments in many behavioural traits mediated by the lack of maternal care. This thesis summarizes current knowledge of endocrinological and behavioural consequences of early postnatal stress...
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